What is the AN 627 Pill? Uses and Effects of Tramadol

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March 27, 2025

The AN 627 pill is a white, round tablet that contains 50 mg of tramadol hydrochloride, a prescription medication used to treat moderate to moderately severe pain. This pill is manufactured by Amneal Pharmaceuticals and is identified by its distinctive “AN 627” imprint.

As a prescription-only medication, tramadol plays an important role in pain management, but it also comes with understanding the proper use, potential side effects, and risks that should be understood by anyone taking this medication.

If you or a loved one is struggling with Tramadol use, Music City Detox offers compassionate care and drug rehab in Nashville to help you regain control.

What is the AN 627 Pill?

The AN 627 pill is a specific formulation of tramadol hydrochloride, an opioid analgesic medication.

The white, round tablet is marked with “AN 627” on one side to allow for proper identification. This particular pill contains 50 mg of tramadol, which is one of the standard dosages prescribed for pain management.

The AN 627 pill is an opioid class of medications. However, tramadol is considered a “weak” opioid and works somewhat differently than traditional opioids like morphine or oxycodone, giving it a unique profile in terms of both efficacy and side effects.

What Is The AN 627 Pill Used For?

The primary use of the AN 627 pill is for pain management. Specifically, tramadol is indicated for:

Moderate to moderately severe pain
Chronic pain conditions
Post-surgical pain
Injury-related pain
Some cases of neuropathic pain (pain caused by nerve damage)

Unlike over-the-counter pain relievers such as acetaminophen or ibuprofen, tramadol requires a prescription due to its mechanism of action and potential for side effects.

It’s typically prescribed when non-opioid pain medications haven’t provided sufficient relief or aren’t appropriate for the patient’s condition.

How Does Tramadol Hydrochloride Work?

Tramadol works through a dual mechanism of action:

Opioid activity: Tramadol binds to μ-opioid receptors in the central nervous system, although with less affinity than stronger opioids. This binding helps block pain signals.
Inhibition of neurotransmitter reuptake: Tramadol inhibits the reuptake of norepinephrine and serotonin, two neurotransmitters involved in pain signaling pathways. This action is similar to some antidepressant medications and contributes to tramadol’s pain-relieving properties.

This dual mechanism makes tramadol unique among pain medications and explains why it may be effective for certain types of pain that don’t respond well to other analgesics.

When Do I Take The AN 627 Pill?

Tramadol should be taken exactly as prescribed by your healthcare provider. Typical dosing guidelines include:

Initial dosing often starts at 50-100 mg (1-2 AN 627 pills) every 4-6 hours as needed for pain
Maximum daily dosage should not exceed 400 mg for most adults
For elderly people, or those with certain medical conditions, lower doses may be prescribed
The medication can be taken with or without food, although taking it with food may help reduce stomach upset

It’s important never to take more than prescribed, take it more frequently than directed, or continue use beyond the prescribed duration without consulting your healthcare provider.

Side Effects of The AN 627 Pill

Like all medications, tramadol can cause side effects.

Common side effects include:

Dizziness or lightheadedness
Drowsiness
Headache
Constipation
Nausea or vomiting
Dry mouth
Sweating

More serious side effects that require immediate medical attention include:

Seizures
Serotonin syndrome (confusion, rapid heart rate, fever, muscle stiffness)
Allergic reactions (rash, itching, swelling, severe dizziness)
Respiratory depression (slow or shallow breathing)
Mental status changes or confusion
Severe dizziness or fainting

Clients should report any unusual or severe side effects to their healthcare provider promptly.

Risks of Stopping AN 627 Pill

Abruptly stopping tramadol, especially after prolonged use, can lead to withdrawal symptoms. These may include:

Anxiety and restlessness
Insomnia
Pain
Excessive sweating
Nausea or vomiting
Diarrhea
Runny nose
Chills
Muscle aches
Irritability

To avoid withdrawal symptoms, tramadol should be tapered gradually under medical supervision when discontinuation is necessary.

Your healthcare provider will create a tapering schedule based on your dosage and duration of use.

Interactions of AN 627 With Other Medications

The AN 627 pill can interact with numerous other medications, potentially causing adverse effects or reducing effectiveness. These interactions can be serious and even life-threatening in some cases.

Opioids

Combining tramadol with other opioid medications can increase the risk of:

Severe drowsiness
Respiratory depression
Coma
Death

This includes prescription opioids like oxycodone, hydrocodone, morphine, and fentanyl, as well as illicit opioids. Healthcare providers will generally avoid prescribing multiple opioids simultaneously due to these risks.

Antidepressants

Tramadol interactions with antidepressants are particularly concerning due to the risk of serotonin syndrome, a potentially life-threatening condition.

Medications that may interact include:

Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine, sertraline, or escitalopram
Serotonin-norepinephrine reuptake inhibitors (SNRIs) like duloxetine or venlafaxine
Tricyclic antidepressants like amitriptyline
Monoamine oxidase inhibitors (MAOIs)

If you’re taking antidepressants, your healthcare provider should carefully evaluate the risks and benefits before prescribing tramadol.

Other Drugs That Can Interact with the AN 627 Pill

Beyond opioids and antidepressants, tramadol can interact with numerous other medications:

Benzodiazepines (such as alprazolam, diazepam): Can increase sedation and respiratory depression
Muscle relaxants: May enhance central nervous system depression
Sleep medications: Can increase sedation effects
Anticonvulsants: May increase seizure risk or alter tramadol metabolism
Certain antibiotics: Can affect how tramadol is processed in the body
CYP2D6 inhibitors: Can affect tramadol metabolism, potentially increasing side effects
CYP3A4 inhibitors or inducers: Can alter tramadol levels in the bloodstream
Warfarin and other blood thinners: May increase bleeding risk

Always provide your healthcare provider with a complete list of all medications, supplements, and herbal products you use to avoid potentially dangerous interactions.

Risks Of Taking Tramadol

While tramadol can be effective for pain management, it carries several important risks:

Respiratory depression: Like other opioids, tramadol can slow breathing, which can be dangerous, especially at higher doses or when combined with other depressants.
Seizure risk: Tramadol lowers the seizure threshold and may trigger seizures, particularly in people with a history of seizures or when taken at high doses.
Serotonin syndrome: Due to its effects on serotonin, tramadol can cause this potentially life-threatening condition, especially when combined with other serotonergic medications.
Dependence and addiction: Though less likely than with stronger opioids, physical dependence and addiction are possible with tramadol.
Tolerance: Over time, the body may require higher doses to achieve the same pain relief.
Mental effects: Tramadol may cause confusion, hallucinations, or changes in mood, especially in elderly patients.

Can You Overdose on a 627 Pill?

Yes, it is possible to overdose on tramadol. An overdose can occur from taking too much at once or from combining it with other substances that enhance its effects. Signs of overdose may include:

Extreme drowsiness or loss of consciousness
Pinpoint pupils
Slowed or stopped breathing
Blue lips or skin
Cold, clammy skin
Seizures
Cardiac arrest

A tramadol overdose is a medical emergency requiring immediate attention.

If you suspect an overdose, call emergency services (911) immediately. Naloxone (Narcan) may be used to reverse the opioid effects, though additional treatments may be needed due to tramadol’s unique properties.

Is Tramadol Addictive?

While tramadol was once considered to have a lower addiction potential than traditional opioids, research and clinical experience have shown that it can indeed be addictive.

In 2014, the DEA reclassified tramadol as a Schedule IV controlled substance in recognition of this risk.

Factors that increase addiction risk include:

History of substance abuse
Family history of addiction
Concurrent mental health conditions
Taking higher doses than prescribed
Taking the medication for longer than prescribed
Using the medication for purposes other than pain relief

Signs of tramadol addiction may include:

Craving the medication
Continuing to use despite negative consequences
Taking larger doses than prescribed
“Doctor shopping” to obtain multiple prescriptions
Withdrawal symptoms when attempting to stop
Neglecting responsibilities due to medication use

If you or someone you know is struggling with tramadol dependence or addiction, speak with a healthcare provider. Treatment options are available and typically involve medically supervised detox followed by counseling or other forms of addiction treatment.

Find Help For Tramadol Dependence Today

If you believe you or someone you know may be developing dependence on tramadol, don’t hesitate to seek help.

At Music City Detox, our addiction treatment programs in Nashville can help you find help and healing from Tramadol abuse.

Call us now at 615-695-1009 or verify your insurance.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider for advice regarding your specific medical condition and treatment options.